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  1. Solitary death (kodokushi) has recently become recognized as a social issue in Japan. The social isolation of older people leads to death without dignity. With the outbreak of COVID-19, efforts to eliminate solit...

    Authors: Eisuke Nakazawa, Keiichiro Yamamoto, Alex John London and Akira Akabayashi
    Citation: BMC Medical Ethics 2021 22:89
  2. Media have increasingly reported on the difficulties associated with end-of-life decision-making in patients with Disorders of Consciousness (DOC), contextualizing such dilemma in detailed accounts of the pati...

    Authors: Mario Picozzi, Lino Panzeri, Davide Torri and Davide Sattin
    Citation: BMC Medical Ethics 2021 22:88
  3. The last few decades have seen the rising global acknowledgment of the importance of ethics in the conduct of health research. But research ethics committees or institutional review boards (IRBs) have also bee...

    Authors: Gideon Lasco, Vincen Gregory Yu and Lia Palileo-Villanueva
    Citation: BMC Medical Ethics 2021 22:85
  4. The pursuit of a cure for HIV is a high priority for researchers, funding agencies, governments and people living with HIV (PLWH). To date, over 250 biomedical studies worldwide are or have been related to dis...

    Authors: Karine Dubé, John Kanazawa, Jeff Taylor, Lynda Dee, Nora Jones, Christopher Roebuck, Laurie Sylla, Michael Louella, Jan Kosmyna, David Kelly, Orbit Clanton, David Palm, Danielle M. Campbell, Morénike Giwa Onaiwu, Hursch Patel, Samuel Ndukwe…
    Citation: BMC Medical Ethics 2021 22:83
  5. Decision-making in out-of-hospital cardiac arrest should ideally include clinical and ethical factors. Little is known about the extent of ethical considerations and their influence on prehospital resuscitatio...

    Authors: Louise Milling, Lars Grassmé Binderup, Caroline Schaffalitzky de Muckadell, Erika Frischknecht Christensen, Annmarie Lassen, Helle Collatz Christensen, Dorthe Susanne Nielsen and Søren Mikkelsen
    Citation: BMC Medical Ethics 2021 22:82
  6. The advent of learning healthcare systems (LHSs) raises an important implementation challenge concerning how to request and manage consent to support secondary use of data in learning cycles, particularly rese...

    Authors: Annabelle Cumyn, Adrien Barton, Roxanne Dault, Nissrine Safa, Anne-Marie Cloutier and Jean-François Ethier
    Citation: BMC Medical Ethics 2021 22:81
  7. During the arrival of the COVID-19 pandemic, various professional ethical guidance was issued to (and for) health and social care professionals in England and Wales. Guidance can help to inform and support suc...

    Authors: Helen Smith, Peta Coulson-Smith, Mari-Rose Kennedy, Giles Birchley, Jonathan Ives and Richard Huxtable
    Citation: BMC Medical Ethics 2021 22:78
  8. Engagement is important within cohort studies for a number of reasons. It is argued that engaging participants within the studies they are involved in may promote their recruitment and retention within the stu...

    Authors: Cynthia A. Ochieng, Joel T. Minion, Andrew Turner, Mwenza Blell and Madeleine J. Murtagh
    Citation: BMC Medical Ethics 2021 22:77
  9. In the initial phase of the Covid-19 pandemic, difficult decisions had to be made on the allocation of testing resources. Similar situations can arise in future pandemics. Therefore, careful consideration of w...

    Authors: Sven Ove Hansson, Gert Helgesson and Niklas Juth
    Citation: BMC Medical Ethics 2021 22:76
  10. Implementing the routine consultation of patient advance directives in hospital emergency departments and emergency medical services has become essential, given that advance directives constitute the frame of ...

    Authors: Silvia Poveda-Moral, Pilar José-Maria de la Casa, Pere Sánchez-Valero, Núria Pomares-Quintana, Mireia Vicente-García and Anna Falcó-Pegueroles
    Citation: BMC Medical Ethics 2021 22:75
  11. Research misconduct is a global concern in biomedical science. There are no comprehensive data regarding the perception and situation of scientific misconduct among the Iranian medical faculty members. We cond...

    Authors: Erfan Shamsoddin, Zahra Torkashvand-Khah, Ahmad Sofi-Mahmudi, Leila Janani, Payam Kabiri, Ehsan Shamsi-Gooshki and Bita Mesgarpour
    Citation: BMC Medical Ethics 2021 22:74
  12. The COVID-19 pandemic has created ethical challenges for intensive care unit (ICU) professionals, potentially causing moral distress. This study explored the levels and causes of moral distress and the ethical...

    Authors: Moniek A. Donkers, Vincent J. H. S. Gilissen, Math J. J. M. Candel, Nathalie M. van Dijk, Hans Kling, Ruth Heijnen-Panis, Elien Pragt, Iwan van der Horst, Sebastiaan A. Pronk and Walther N. K. A. van Mook
    Citation: BMC Medical Ethics 2021 22:73
  13. The Life Extension Medical Decision law enacted on February 4, 2018 in South Korea was the first to consider the suspension of futile life-sustaining treatment, and its enactment caused a big controversy in Ko...

    Authors: Yu Jin Chung, Incheol Park, Junho Cho, Jin Ho Beom and Ji Eun Lee
    Citation: BMC Medical Ethics 2021 22:72
  14. The highly sensitive nature of genomic and associated clinical data, coupled with the consent-related vulnerabilities of children together accentuate ethical, legal and social issues (ELSI) concerning data sha...

    Authors: Vasiliki Rahimzadeh, Gillian Bartlett and Bartha Maria Knoppers
    Citation: BMC Medical Ethics 2021 22:71
  15. ECMO is a particularly scarce resource during the COVID-19 pandemic. Its allocation involves ethical considerations that may be different to usual times. There is limited pre-pandemic literature on the ethical...

    Authors: Bernadine Dao, Julian Savulescu, Jacky Y. Suen, John F. Fraser and Dominic J. C. Wilkinson
    Citation: BMC Medical Ethics 2021 22:70
  16. Competent end-of-life care is an essential component of total health care provision, but evidence suggests that it is often deficient. This study aimed to evaluate the knowledge and attitudes about key end-of-...

    Authors: Thashi Chang, Saumya Darshani, Pavithra Manikavasagam and Carukshi Arambepola
    Citation: BMC Medical Ethics 2021 22:66
  17. A different ethos with respect to the perception of medical ethics prevails in societies in transition such as those in the Arabian Peninsula, which makes it difficult to apply international principles of bioe...

    Authors: Ahmed S. Al-Busaidi, Anuradha Ganesh, Samir Al-Adawi, Yahya M. Al-Farsi, Maryam K. Al-Rawahi, Nusaiba A. Al-Mawali, Nadiya S. Al-Kharousi, Mohammed Al-Alawi and Abdullah S. Al-Mujaini
    Citation: BMC Medical Ethics 2021 22:65
  18. Literature shows that middle-aged and older adults sometimes experience a wish to die. Reasons for these wishes may be complex and involve multiple factors. One important question is to what extent people with...

    Authors: Roosmarijne M. K. Kox, H. Roeline W. Pasman, Martijn Huisman, Wim Benneker and Bregje D. Onwuteaka-Philipsen
    Citation: BMC Medical Ethics 2021 22:64
  19. The use of genetic test results in risk-rated insurance is a significant concern internationally, with many countries banning or restricting the use of genetic test results in underwriting. In Australia, life ...

    Authors: Jane Tiller, Aideen McInerney-Leo, Andrea Belcher, Tiffany Boughtwood, Penny Gleeson, Martin Delatycki, Kristine Barlow-Stewart, Ingrid Winship, Margaret Otlowski, Louise Keogh and Paul Lacaze
    Citation: BMC Medical Ethics 2021 22:63
  20. In this article, we address questions regarding how people consider what they do or do not consent to and the reasons why. This article presents the findings of a citizen forum study conducted by the Universit...

    Authors: Minerva C. Rivas Velarde, Petros Tsantoulis, Claudine Burton-Jeangros, Monica Aceti, Pierre Chappuis and Samia Hurst-Majno
    Citation: BMC Medical Ethics 2021 22:62
  21. Research with cerebral organoids is beginning to make significant progress in understanding the etiology of autism spectrum disorder (ASD). Brain organoid models can be grown from the cells of donors with ASD....

    Authors: Andrew J. Barnhart and Kris Dierickx
    Citation: BMC Medical Ethics 2021 22:61
  22. We examine the incidence of medical tribunal decisions and disciplinary actions (DAs) against healthcare professionals (HCPs). In addition, we studied whether an intimate relationship between an HCP and patien...

    Authors: Wim Rietdijk and Sander Renes
    Citation: BMC Medical Ethics 2021 22:60
  23. Definition and concept of the ‘beginning of human life’ are weakened by co-existing contrasting hypotheses based on humanistic or religious beliefs rather than scientific foundations. This plethora of conceptu...

    Authors: Daniela Polese, Marcella Fagioli, Fabio Virgili and Paolo Fiori Nastro
    Citation: BMC Medical Ethics 2021 22:57
  24. Nusinersen is one of an increasing number of new, expensive orphan drugs to receive authorization. These drugs strain public healthcare budgets and challenge principles for resource allocation. Nusinersen was ...

    Authors: Morten Magelssen, Magnhild Rasmussen, Sean Wallace and Reidun Førde
    Citation: BMC Medical Ethics 2021 22:54
  25. Biomedical research nowadays is increasingly carried out in multinational and multicenter settings. Due to disparate national regulations on various ethical aspects, such as informed consent, there is the risk...

    Authors: Marcin Orzechowski, Katarzyna Woniak, Cristian Timmermann and Florian Steger
    Citation: BMC Medical Ethics 2021 22:53
  26. Ethics review is the process of assessing the ethics of research involving humans. The Ethics Review Committee (ERC) is the key oversight mechanism designated to ensure ethics review. Whether or not this gover...

    Authors: Agata Ferretti, Marcello Ienca, Mark Sheehan, Alessandro Blasimme, Edward S. Dove, Bobbie Farsides, Phoebe Friesen, Jeff Kahn, Walter Karlen, Peter Kleist, S. Matthew Liao, Camille Nebeker, Gabrielle Samuel, Mahsa Shabani, Minerva Rivas Velarde and Effy Vayena
    Citation: BMC Medical Ethics 2021 22:51
  27. The areas of Research Ethics (RE) and Research Integrity (RI) are rapidly evolving. Cases of research misconduct, other transgressions related to RE and RI, and forms of ethically questionable behaviors have b...

    Authors: Anna Catharina Vieira Armond, Bert Gordijn, Jonathan Lewis, Mohammad Hosseini, János Kristóf Bodnár, Soren Holm and Péter Kakuk
    Citation: BMC Medical Ethics 2021 22:50
  28. We describe our experience from a multi-national application of a European Union-funded research-driven paediatric trial (DEEP-2, EudraCT 2012-000353-31; NCT01825512). This paper aims to evaluate the impact of...

    Authors: Viviana Giannuzzi, Mariagrazia Felisi, Donato Bonifazi, Hugo Devlieger, George Papanikolaou, Lamis Ragab, Slaheddine Fattoum, Bianca Tempesta, Giorgio Reggiardo and Adriana Ceci
    Citation: BMC Medical Ethics 2021 22:49
  29. Efforts to build research capacity and capability in low and middle income countries (LMIC) has progressed over the last three decades, yet it confronts many challenges including issues with communicating or e...

    Authors: Rakhshi Memon, Muqaddas Asif, Ameer B. Khoso, Sehrish Tofique, Tayyaba Kiran, Nasim Chaudhry, Nusrat Husain and Sarah J. L. Edwards
    Citation: BMC Medical Ethics 2021 22:47
  30. In modern Russia, any clinical investigation of a pharmaceutical for use in humans is subject to prior evaluation and approval by the Ministry of Health and its Central Ethics Committee. Despite this, some res...

    Authors: Petr Talantov, Ravil Niyazov, Galina Viryasova, Margarita Dranitsyna and Ilya Yasny
    Citation: BMC Medical Ethics 2021 22:46
  31. Ethics consult services are well established, but often remain underutilized. Our aim was to identify the barriers and perceptions of the Ethics consult service for physicians, advance practice providers (APPs...

    Authors: Lynette Cederquist, Jamie Nicole LaBuzetta, Edward Cachay, Lawrence Friedman, Cassia Yi, Laura Dibsie and Yiran Zhang
    Citation: BMC Medical Ethics 2021 22:44
  32. Prognostic uncertainty is a challenge for physicians in the neuro intensive care field. Questions about whether continued life-sustaining treatment is in a patient’s best interests arise in different phases af...

    Authors: Annette Robertsen, Eirik Helseth and Reidun Førde
    Citation: BMC Medical Ethics 2021 22:43
  33. Little is known about volunteers from Northern research settings who participate in vaccine trials of highly infectious diseases with no approved treatments. This article explores the motivations of HIV immuno...

    Authors: Pierre-Marie David, Benjamin Mathiot, Oumy Thiongane and Janice E. Graham
    Citation: BMC Medical Ethics 2021 22:42

    The Correction to this article has been published in BMC Medical Ethics 2021 22:69

  34. Suicide research aims to contribute to a better understanding of suicidal behaviour and its prevention. However, there are many ethical challenges in this research field, for example, regarding consent and pot...

    Authors: Emma Barnard, Georgia Dempster, Karolina Krysinska, Lennart Reifels, Jo Robinson, Jane Pirkis and Karl Andriessen
    Citation: BMC Medical Ethics 2021 22:41

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