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  2. Definition and concept of the ‘beginning of human life’ are weakened by co-existing contrasting hypotheses based on humanistic or religious beliefs rather than scientific foundations. This plethora of conceptu...

    Authors: Daniela Polese, Marcella Fagioli, Fabio Virgili and Paolo Fiori Nastro

    Citation: BMC Medical Ethics 2021 22:57

    Content type: Debate

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  5. Nusinersen is one of an increasing number of new, expensive orphan drugs to receive authorization. These drugs strain public healthcare budgets and challenge principles for resource allocation. Nusinersen was ...

    Authors: Morten Magelssen, Magnhild Rasmussen, Sean Wallace and Reidun Førde

    Citation: BMC Medical Ethics 2021 22:54

    Content type: Research

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  6. Biomedical research nowadays is increasingly carried out in multinational and multicenter settings. Due to disparate national regulations on various ethical aspects, such as informed consent, there is the risk...

    Authors: Marcin Orzechowski, Katarzyna Woniak, Cristian Timmermann and Florian Steger

    Citation: BMC Medical Ethics 2021 22:53

    Content type: Research

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  8. Ethics review is the process of assessing the ethics of research involving humans. The Ethics Review Committee (ERC) is the key oversight mechanism designated to ensure ethics review. Whether or not this gover...

    Authors: Agata Ferretti, Marcello Ienca, Mark Sheehan, Alessandro Blasimme, Edward S. Dove, Bobbie Farsides, Phoebe Friesen, Jeff Kahn, Walter Karlen, Peter Kleist, S. Matthew Liao, Camille Nebeker, Gabrielle Samuel, Mahsa Shabani, Minerva Rivas Velarde and Effy Vayena

    Citation: BMC Medical Ethics 2021 22:51

    Content type: Debate

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  9. The areas of Research Ethics (RE) and Research Integrity (RI) are rapidly evolving. Cases of research misconduct, other transgressions related to RE and RI, and forms of ethically questionable behaviors have b...

    Authors: Anna Catharina Vieira Armond, Bert Gordijn, Jonathan Lewis, Mohammad Hosseini, János Kristóf Bodnár, Soren Holm and Péter Kakuk

    Citation: BMC Medical Ethics 2021 22:50

    Content type: Research article

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  10. We describe our experience from a multi-national application of a European Union-funded research-driven paediatric trial (DEEP-2, EudraCT 2012-000353-31; NCT01825512). This paper aims to evaluate the impact of...

    Authors: Viviana Giannuzzi, Mariagrazia Felisi, Donato Bonifazi, Hugo Devlieger, George Papanikolaou, Lamis Ragab, Slaheddine Fattoum, Bianca Tempesta, Giorgio Reggiardo and Adriana Ceci

    Citation: BMC Medical Ethics 2021 22:49

    Content type: Research

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  12. Efforts to build research capacity and capability in low and middle income countries (LMIC) has progressed over the last three decades, yet it confronts many challenges including issues with communicating or e...

    Authors: Rakhshi Memon, Muqaddas Asif, Ameer B. Khoso, Sehrish Tofique, Tayyaba Kiran, Nasim Chaudhry, Nusrat Husain and Sarah J. L. Edwards

    Citation: BMC Medical Ethics 2021 22:47

    Content type: Debate

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  13. In modern Russia, any clinical investigation of a pharmaceutical for use in humans is subject to prior evaluation and approval by the Ministry of Health and its Central Ethics Committee. Despite this, some res...

    Authors: Petr Talantov, Ravil Niyazov, Galina Viryasova, Margarita Dranitsyna and Ilya Yasny

    Citation: BMC Medical Ethics 2021 22:46

    Content type: Research

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  15. Ethics consult services are well established, but often remain underutilized. Our aim was to identify the barriers and perceptions of the Ethics consult service for physicians, advance practice providers (APPs...

    Authors: Lynette Cederquist, Jamie Nicole LaBuzetta, Edward Cachay, Lawrence Friedman, Cassia Yi, Laura Dibsie and Yiran Zhang

    Citation: BMC Medical Ethics 2021 22:44

    Content type: Research article

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  16. Prognostic uncertainty is a challenge for physicians in the neuro intensive care field. Questions about whether continued life-sustaining treatment is in a patient’s best interests arise in different phases af...

    Authors: Annette Robertsen, Eirik Helseth and Reidun Førde

    Citation: BMC Medical Ethics 2021 22:43

    Content type: Research article

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  17. Little is known about volunteers from Northern research settings who participate in vaccine trials of highly infectious diseases with no approved treatments. This article explores the motivations of HIV immuno...

    Authors: Pierre-Marie David, Benjamin Mathiot, Oumy Thiongane and Janice E. Graham

    Citation: BMC Medical Ethics 2021 22:42

    Content type: Research article

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    The Correction to this article has been published in BMC Medical Ethics 2021 22:69

  18. Suicide research aims to contribute to a better understanding of suicidal behaviour and its prevention. However, there are many ethical challenges in this research field, for example, regarding consent and pot...

    Authors: Emma Barnard, Georgia Dempster, Karolina Krysinska, Lennart Reifels, Jo Robinson, Jane Pirkis and Karl Andriessen

    Citation: BMC Medical Ethics 2021 22:41

    Content type: Research article

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  19. This paper highlights the issues that one of the 90 Italian Research Ethics Committees (RECs) might encounter during the approval phase of a clinical trial to identify corrective and preventive actions for pro...

    Authors: G. Benfatto and F. Drago

    Citation: BMC Medical Ethics 2021 22:40

    Content type: Research article

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    The Correction to this article has been published in BMC Medical Ethics 2021 22:52

  20. Genetics and genomics research (GGR) is increasingly being conducted around the world; yet, researchers and research oversight entities in many countries have struggled with ethical challenges. A range of ethi...

    Authors: Joseph Ali, Betty Cohn, Erisa Mwaka, Juli M. Bollinger, Betty Kwagala, John Barugahare, Nelson K. Sewankambo and Joseph Ochieng

    Citation: BMC Medical Ethics 2021 22:39

    Content type: Research article

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  21. The proper and ethical inclusion of PWLHIV and their young children in research is paramount to ensure valid evidence is generated to optimize treatment and care. Little empirical data exists to inform ethical...

    Authors: Catherine G. Raciti, Leslie A. Enane, Katherine R. MacDonald, Elizabeth C. Whipple, Mary A. Ott and Megan S. McHenry

    Citation: BMC Medical Ethics 2021 22:38

    Content type: Research article

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  22. The transplantation of porcine islet cells provides a new potential therapy to treat patients with type 1 diabetes mellitus (T1DM). Compared to other biomedical technologies, xenotransplantation stands out in ...

    Authors: Johannes Kögel, Sandra Thiersch, Barbara Ludwig, Jochen Seissler and Georg Marckmann

    Citation: BMC Medical Ethics 2021 22:37

    Content type: Research article

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  24. Whereas many adolescents and young people with HIV require the transfer of care from paediatric/adolescent clinics to adult ART clinics, this transition is beset with a multitude of factors that have the poten...

    Authors: Scovia Nalugo Mbalinda, Sabrina Bakeera-Kitaka, Derrick Lusota Amooti, Eleanor Namusoke Magongo, Philippa Musoke and Dan Kabonge Kaye

    Citation: BMC Medical Ethics 2021 22:35

    Content type: Research article

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  25. The values and attitudes of healthcare professionals influence their handling of ‘do-not-attempt-resuscitation’ (DNAR) orders. The aim of this study was a) to describe attitudes, perceptions and practices amon...

    Authors: Anders Bremer, Kristofer Årestedt, Ewa Rosengren, Jörg Carlsson and Samuel Sandboge

    Citation: BMC Medical Ethics 2021 22:34

    Content type: Research article

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  26. Informed consent is a prerequisite for caesarean section, the commonest surgical procedure in low- and middle-income settings, but not always acquired to an appropriate extent. Exploring perceptions of health ...

    Authors: Wouter Bakker, Siem Zethof, Felix Nansongole, Kelvin Kilowe, Jos van Roosmalen and Thomas van den Akker

    Citation: BMC Medical Ethics 2021 22:33

    Content type: Research article

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  27. When including participants with dementia in research, various ethical issues arise. At present, there are only a few existing dementia-specific research guidelines (Committee for Medicinal Products for Human ...

    Authors: Tim G. Götzelmann, Daniel Strech and Hannes Kahrass

    Citation: BMC Medical Ethics 2021 22:32

    Content type: Research article

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  29. As opioid use disorder (OUD) incidence and its associated deaths continue to persist at elevated rates, the development of novel treatment modalities is warranted. Recent strides in this therapeutic area inclu...

    Authors: Vincent Wartenweiler, Grace Chung, Amy Stewart and Cody Wenthur

    Citation: BMC Medical Ethics 2021 22:30

    Content type: Research article

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  30. Immense volumes of personal health information (PHI) are required to realize the anticipated benefits of artificial intelligence in clinical medicine. To maintain public trust in medical research, consent poli...

    Authors: Sarah Tosoni, Indu Voruganti, Katherine Lajkosz, Flavio Habal, Patricia Murphy, Rebecca K. S. Wong, Donald Willison, Carl Virtanen, Ann Heesters and Fei-Fei Liu

    Citation: BMC Medical Ethics 2021 22:29

    Content type: Research article

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  31. The worsening COVID-19 pandemic in South Africa poses multiple challenges for clinical decision making in the context of already-scarce ICU resources. Data from national government and the last published natio...

    Authors: Reshania Naidoo and Kantharuben Naidoo

    Citation: BMC Medical Ethics 2021 22:28

    Content type: Debate

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  32. In childhood cancer care, healthcare professionals must deal with several difficult moral situations in clinical practice. Previous studies show that morally difficult challenges are related to decisions on tr...

    Authors: Charlotte Weiner, Pernilla Pergert, Bert Molewijk, Anders Castor and Cecilia Bartholdson

    Citation: BMC Medical Ethics 2021 22:27

    Content type: Research article

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  33. Critical Incident Reporting Systems (CIRS) provide a well-proven method to identify clinical risks in hospitals. All professions can report critical incidents anonymously, low-threshold, and without sanctions....

    Authors: Kai Wehkamp, Eva Kuhn, Rainer Petzina, Alena Buyx and Annette Rogge

    Citation: BMC Medical Ethics 2021 22:26

    Content type: Research article

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  36. Medical assistance in dying (MAID) has been legal in Québec since December 2015 and in the rest of Canada since July 2016. Since then, more than 60 people have donated their organs after MAID. Such donations r...

    Authors: Julie Allard, Fabian Ballesteros and Marie-Chantal Fortin

    Citation: BMC Medical Ethics 2021 22:23

    Content type: Research article

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  37. The COVID-19 pandemic has presented extraordinary challenges to worldwide healthcare systems, however, prevalence remains low in some countries. While the challenges of conducting research in high-prevalence c...

    Authors: Tony Skapetis, Constance Law and Rohan Rodricks

    Citation: BMC Medical Ethics 2021 22:22

    Content type: Research article

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  38. In the context of translational research, researchers have increasingly been using biological samples and data in fundamental research phases. To explore informed consent practices, we conducted a retrospectiv...

    Authors: Elise Jacquier, Pierre Laurent-Puig, Cécile Badoual, Anita Burgun and Marie-France Mamzer

    Citation: BMC Medical Ethics 2021 22:21

    Content type: Research article

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  39. The theory and practice of ethics consultations (ECs) in health care are still characterized by many controversies, including, for example, the practice of giving recommendations. These controversies are compl...

    Authors: Dagmar Schmitz, Dominik Groß and Roman Pauli

    Citation: BMC Medical Ethics 2021 22:20

    Content type: Research article

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  40. Fecal microbiota transplant (FMT) is a treatment modality that involves the introduction of stool from a healthy pre-screened donor into the gastrointestinal tract of a patient. It exerts its therapeutic effec...

    Authors: Amal G. Al-Bakri, Amal A. Akour and Wael K. Al-Delaimy

    Citation: BMC Medical Ethics 2021 22:19

    Content type: Research article

    Published on:

  41. Providing understandable information to patients is necessary to achieve the aims of the Informed Consent process: respecting and promoting patients’ autonomy and protecting patients from harm. In recent decad...

    Authors: Francesco Gesualdo, Margherita Daverio, Laura Palazzani, Dimitris Dimitriou, Javier Diez-Domingo, Jaime Fons-Martinez, Sally Jackson, Pascal Vignally, Caterina Rizzo and Alberto Eugenio Tozzi

    Citation: BMC Medical Ethics 2021 22:18

    Content type: Research article

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  42. Advances in biomedicine can substantially change human life. However, progress is not always followed by ethical reflection on its consequences or scientists’ responsibility for their creations. The humanities...

    Authors: Irene Cambra-Badii, Elena Guardiola and Josep-E. Baños

    Citation: BMC Medical Ethics 2021 22:17

    Content type: Debate

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  43. Medical ethics has recently seen a drive away from multiple prescriptive approaches, where physicians are inundated with guidelines and principles, towards alternative, less deontological perspectives. This re...

    Authors: Mervyn Conroy, Aisha Y. Malik, Catherine Hale, Catherine Weir, Alan Brockie and Chris Turner

    Citation: BMC Medical Ethics 2021 22:16

    Content type: Research article

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  45. Artificial intelligence (AI) has been described as the “fourth industrial revolution” with transformative and global implications, including in healthcare, public health, and global health. AI approaches hold ...

    Authors: Kathleen Murphy, Erica Di Ruggiero, Ross Upshur, Donald J. Willison, Neha Malhotra, Jia Ce Cai, Nakul Malhotra, Vincci Lui and Jennifer Gibson

    Citation: BMC Medical Ethics 2021 22:14

    Content type: Research article

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  48. The convergence of neuroscience, genomics, and data science holds promise to unveil the neurobiology of psychosis and to produce new ways of preventing, diagnosing, and treating psychotic illness. Yet, moral c...

    Authors: Paolo Corsico

    Citation: BMC Medical Ethics 2021 22:11

    Content type: Research article

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  49. Informed consent is a universally accepted precondition for scientific researches involving human participants. However, various factors influence the process of obtaining authentic informed consent, and resea...

    Authors: Tesfalem T. Tessema, Andamlak G. Alamdo, Eyoel B. Mekonnen, Fanna A. Debele, Juhar A. Bamud, Teklu G. Abessa and Tefera Belachew Lema

    Citation: BMC Medical Ethics 2021 22:10

    Content type: Research article

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  50. This manuscript presents a framework to guide the identification and assessment of ethical opportunities and challenges associated with electronic patient records (EPR). The framework is intended to support de...

    Authors: Tim Jacquemard, Colin P. Doherty and Mary B. Fitzsimons

    Citation: BMC Medical Ethics 2021 22:9

    Content type: Research article

    Published on:

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BMC Medical Ethics

ISSN: 1472-6939

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