National Research Council Committee on Recognition and Alleviation of Distress in Laboratory Animals. Recognition and alleviation of distress in laboratory animals. Washington, DC: National Academies Press; 2008.
National Research Council Committee on recognition and alleviation of pain in laboratory animals. Recognition and alleviation of pain in laboratory animals. Washington DC: National Academies Press; 2009.
Rollin BE. Animal research: a moral science. EMBO Rep. 2007;8(6):521–5.
Robert B. Lives in the balance: utilitarianism and AR. In: Garrett JR, editor. The ethics of animal research: exploring the controversy. USA: MIT; 2012. p. 81–105.
Matthews RAJ. Medical progress depends on animal models- doesn’t it? J R Soc Med. 2008;101(2):95–8.
Bara M, Joffe AR. The methodological quality of animal research in critical care: the public face of science. Annals Intensive Care. 2014;4:26.
Killkenny C, Parsons N, Kadyszewski E, Festing MFW, Cuthill IC, Fry D, et al. Survey of the quality of experimental design, statistical analysis and reporting of research using animals. PLoS One. 2009;4(11):e7284.
Sena E, van der Worp B, Howells D, Macleod M. How can we improve the preclinical development of drugs for stroke? Trends Neurosci. 2007;30:433–9.
Baginskait J. Scientific Quality Issues in the Design and Reporting of Bioscience Research: A Systematic Study of Randomly Selected Original In Vitro, In Vivo and Clinical Study Articles Listed in the PubMed Database. In CAMARADES Monogr 2012. [http://www.dcn.ed.ac.uk/camarades/files/Camarades%20Monograph%20201201.pdf ].
Baker D, Lidster K, Sottomayor A, Amor S. Two years later: journals are not yet enforcing the ARRIVE guidelines on reporting standards for pre-clinical animal studies. PLoS Biol. 2014;12(1):e1001756.
Bara M, Joffe AR. The ethical dimension in published animal research in critical care: the public face of science. Crit Care. 2014;18(1):R15.
Carbone L. Pain in laboratory animals: the ethical and regulatory imperatives. PLoS One. 2011;6:e21578.
Scott S, Kranz JE, Cole J, Lincecum JM, Thompson K, Kelly N, et al. Design, power, and interpretation of studies in the standard murine model of ALS. Amyotroph Lateral Scler. 2008;9:4–15.
Steward O, Popovich PG, Dietrich WD, Kleitman N. Replication and reproducibility in spinal cord injury research. Exp Neurol. 2012;233:597–605.
Horrobin DF. Modern biomedical research: an internally self-consistent universe with little contact with medical reality. Nat Rev Drug Discov. 2003;2:151–4.
Pippin JJ. AR in medical sciences: seeking a convergence of science, medicine, and animal law. South Texas Law Rev. 2013;54:469–511.
Shanks N, Greek R, Greek J. Are animal models predictive for humans? Phil Ethics Humanities Med. 2009;4:2.
Pound P, Bracken MB. Is AR sufficiently evidence based to be a cornerstone of biomedical research? BMJ. 2014;348:g3387.
Dyson A, Singer M. Animal models of sepsis: why does preclinical efficacy fail to translate to the clinical setting. Crit Care Med. 2009;37(Suppl):S30–7.
Opal SM, Patrozou E. Translational research in the development of novel sepsis therapeutics: logical deductive reasoning or mission impossible? Crit Care Med. 2009;37(Suppl):S10–5.
Fink MP. Animal models of sepsis. Virulence. 2013;5(1):143–53.
Jauch EC, Saver JL, Adams HP, Bruno Jr A, Connors JJ, Demaerschalk BM, et al. Guidelines for the early management of patients with acute ischemic stroke: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2013;44:870–947.
Sutherland BA, Minnerup J, Balami JS, Arba F, Buchan AM, Kleinschnitz C. Neuroprotection for ischemic stroke: translation from the bench to the bedside. Int J Stoke. 2012;7:407–18.
Akhtar AZ, Pippin JJ, Sandusky CB. Animal models of spinal cord injury: a review. Rev Neurosci. 2009;19:47–60.
Domingo A, Al-Yahya AA, Asiri Y, Eng JJ, Lam T. A systematic review of the effects of pharmacological agents on walking function in people with spinal cord injury. J Neurotrauma. 2012;29:865–79.
Xiong Y, Mahmood A, Chopp M. Animal models of traumatic brain injury. Nat Rev Neurosci. 2013;14:128–42.
Begley CG, Ellis LM. Drug development: raise standards for preclinical cancer research. Nature. 2012;483:531–3.
Hutchinson L, Kirk R. High drug attrition rates- where are we going wrong? Nat Rev Clin Oncol. 2011;8:189.
Ransohoff RM. Animal models of multiple sclerosis: the good, the bad and the bottom line. Nat Neurosci. 2012;15:1074–7.
Geerts H. Of mice and men: bridging the translational disconnect in CNS drug discovery. CNS Drugs. 2009;23(11):915–26.
Hatziioannou T, Evans DT. Animal models for HIV/AIDS research. Nat Rev Microbiol. 2012;10:852–67.
Holmes AM, Solari R, Holgate ST. Animal models of asthma: value, limitations and opportunities for alternative approaches. Drug Discov Today. 2011;16(15–16):659–70.
Pammolli F, Magazzini L, Riccaboni M. The productivity crisis in pharmaceutical R&D. Nat Rev Drug Discov. 2011;10:428–38.
DiMasi JA, Feldman L, Seckler A, Wilson A. Trends in risks associated with new drug development: success rates for investigational drugs. Clin Pharmacol Ther (St Louis, MO, U S). 2010;87(3):272–7.
Fourches D, Barnes JC, Day NC, Bradley P, Reed JZ, Tropsha A. Chemoinformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chem Res Toxicol. 2010;23:171–83.
Hartung T. Toxicology for the twenty-first century. Nature. 2009;460:208–12.
Knight A. The costs and benefits of animal experiments. UK: Palgrave Macmillan; 2011.
Card JW, Fikree H, Haighton LA, Lee-Brotherton V, Wan J, Sangster B. Lack of human tissue-specific correlations for rodent pancreatic and colorectal carcinogens. Reg Toxicol Pharm. 2012;64:442–58.
Knight A, Bailey J, Balcombe J. Animal carcinogenicity studies: 1. Poor human predictivity. Altern Lab Anim. 2006;34:19–27.
Greek R, Shanks N, Rice MJ. The history and implications of testing thalidomide on animals. J Philos Sci Law. 2011;11:1–32. http://jpsl.org/archives/history-and-implications-testing-thalidomide-animals/.
Ipsos MOR. Views on the use of animals in scientific research. Dept for Business Innovation & Skills; 2012. [file:///C:/DOCUME ~ 1/arijoffe/LOCALS ~ 1/Temp/1512_sri-BIS_animal_research_2012_final_report_September_published_final.pdf]
Harris PA, Taylor R, Thielke R, Payne J, Gonzalez N, Conde JG. Research Electronic Data Capture (REDCap)- a meta-data driven methodology and workflow process for providing translational research informatics support. J Biomed Inform. 2009;42(2):377–81.
Burns KEA, Duffett M, Kho ME, Meade MO, Adhikari NKJ, Sinuff T, et al. A guide for the design and conduct of self-administered surveys of clinicians. CMAJ. 2008;179(3):245–52.
European Commission. Eurobarometer: science and technology report: European Commission, June 2010: 60–64. [http://ec.europa.eu/public_opinion/archives/ebs/ebs_340_en.pdf]
CrettazvonRoten F. European attitudes towards animal research: overview and consequences for science. Sci Technol Soc. 2009;14(2):349–64.
Goodman JR, Borch CA, Cherry E. Mounting opposition to vivisection. Contexts. 2012;11(2):68–9.
Masterton M, Renberg T, Sporrong SK. Patients’ attitudes towards animal testing: ‘To conduct research on animals is, I suppose, a necessary evil’. BioSocieties. 2014;9:24–41.
Knight S, Vrij A, Bard K, Brandon D. Science versus human welfare? Understanding attitudes toward animal use. J Soc Issues. 2009;65(3):463–83.
Ormandy EH, Schuppli CA, Weary DM. Public attitudes toward the use of animals in research: effects of invasiveness, genetic modification and regulation. Anthropozoos. 2013;26(2):165–84.
Macnaghten P. Animals in their nature: a case study on public attitudes to animals, genetic modification and ‘nature’. Sociology. 2004;38(3):533–51.
Hobson-West P. Ethical boundary-work in the animal research laboratory. Sociology. 2012;46(4):749–663.
Hobson-West P. The role of ‘public opinion’ in the UK animal research debate. J Med Ethics. 2010;36:46–9.
Hobson-West P. What kind of animal is the ‘Three Rs’? ATLA. 2009;37(Suppl2):95–9.
Greek R, Rice MJ. Animal models and conserved processes. Theor Biol Med Model. 2012;9:40.
Greek R, Hansen LA. Questions regarding the predictive value of one evolved complex adaptive system for a second: exemplified by the SOD1 mouse. Progress Biophysics Mol Biol. 2013;113:231–53.
Ahn AC, Tewari M, Poon C, Phillips RS. The limits of reductionism in medicine: could systems biology offer an alternative? PLoS Med. 2006;3(6):e208.
Mazzocchi F. Complexity in biology. EMBO Rep. 2008;9(1):10–4.
Wagner A. Causality in complex systems. Biol Philos. 1999;14:83–101.
Seok J, Warren S, Cuenca AG, Mindrinos MN, Baker HV, Xu W, et al. Genomic responses in mouse models poorly mimic human inflammatory diseases. Proc Natl Acad Sci U S A. 2013;110:3507–12.
Gentile LF, Nacionales DC, Lopez C, Vanzant E, Cuenca A, Cuenca AG, et al. A better understanding of why murine models of trauma do not recapitulate the human syndrome. Crit Care Med. 2014;42(6):1406–13.
Brawand D, Soumillon M, Necsulea A, Julien P, Csardi G, Harrigan P, et al. The evolution of gene expression levels in mammalian organs. Nature. 2011;478:343–8.
Varki NM, Strobert E, Dick Jr EJ, Benirschke K, Varki A. Biomedical differences between human and nonhuman hominids: potential roles for uniquely human aspects of sialic acid biology. Annual Rev Pathol Mechanisms Dis. 2011;6:365–93.
Kilkenny C, Browne WJ, Cuthill IC, Emerson M, Altman DG. Improving bioscience research reporting: the ARRIVE guidelines for reporting animal research. PLoS Biol. 2010;8(6):e1000412.
Institute for Laboratory Animal Research: National Research Council. Guidance for the Description of Animal Research in Scientific Publications. Washington DC: National Academy of Sciences; 2011.
Canadian Council on Animal Care in Science. CCAC Guidelines on: Animal use Protocol Review. Ottawa: Canadian Council on Animal Care; 1997 http://www.ccac.ca/Documents/Standards/Guidelines/Protocol_Review.pdf.
Woloshin S, Schwartz LM, Casella SL, Kennedy AT, Larson RJ. Press releases by academic medical centers: not so academic? Ann Intern Med. 2009;150:613–8.
Contopoulos-Ioannidis DG, Ntzani EE, Ioannidis JPA. Translation of highly promising basic science research into clinical applications. Am J Med. 2003;114:477–84.
Hackam DG, Redelmeier DA. Translation of research evidence from animals to humans. JAMA. 2006;296(14):1731–2.
Knight A. Systematic reviews of animal experiments demonstrate poor contributions to human healthcare. Rev Recent Clin Trials. 2008;3(2):89–96.