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Table 2 Ethical Issues Encountered in HIV Prevention Research due to the COVID-19 Pandemic and Corresponding HPTN Guidance Points (GP)

From: HIV prevention research and COVID-19: putting ethics guidance to the test

Action/Circumstance Issues GP
Risk Mitigation Physical safety of study participants, research personnel, and community partners
Economic and social risks for study participants
5
Behavior Change Changes in risk behaviors influencing event rates
Changes in use of PrEP and other means of prevention
1
Compounding Vulnerability COVID-19 pandemic disproportionately effects populations many of which are similarly effected by HIV/AIDS
Adverse physical, psychosocial and economic effects
Responding to COVID-19 at the expense of other health concerns
7
Community Engagement Need to maintain community engagement during study interruptions and pauses
Challenges to community engagement
3
Trial Re-opening Potential risk of increasing COVID-19 transmission
Preserving scientific validity and social value of HIV prevention research
1, 5
Shifting Research Priorities Neglecting research on other diseases
Delay in identifying new effective strategies for reducing HIV acquisition in at-risk populations
2