Skip to main content

Table 2 Orphan diseases presented on the television series “House, M.D.” and corresponding orphan drug designations and approvals by the FDA, if present, as well as respective season and episodes

From: Disease awareness or subtle product placement? Orphan diseases featured in the television series “House, M.D.” - a cross-sectional analysis

Orphan diseaseORPHA NumberNumber of compounds with an orphan drug designation (by the FDA)Number of compounds with an orphan drug approval (by the FDA)FDA approved compoundsSeasonEpisode
Sickle cell trait232403Hydroxyurea, L-glutamine72
Mastocytosis98,29283Cromolyn sodium, imatinib mesylate, midostaurin81
Muckle-Wells syndrome57533Anakinra, Canakinumab, Rilonacept714
Ornithine Transcarbamylase Deficiency66442Benzoate and phenylacetate, sodium phenylbutyrate115
Familial Mediterranean fever34232Canakinumab, colchicine56
Fabry disease32491Ceramide trihexosidase/alpha-galactosidase A63
African trypanosomiasis338541Eflornithine HCl17
Acute intermittent porphyria79,27641Hemin122
Leprosy54831Clofazimine113
Diffuse lepromatous leprosy54831Clofazimine51
Wegener’s disease90031Rituximab723
Chronic granulomatous disease37921Interferon gamma 1-b38
Mucormycosis73,26321Isavuconazonium sulfate814
Hereditary coproporphyria79,27321Hemin510
Hereditary Angioedema91,37821C1-esterase-inhibitor35
Thrombotic thrombocytopenic purpura54,05770119
Hereditary hemorrhagic telangiectasia77430316
Senile amyloidosis330,0013033
Alport syndrome632087
Giant cell arteritis39710812
Von Hippel-Lindau syndrome8921042
Wiskott-Aldrich Syndrome90610515
Subacute sclerosing panencephalitis28061012
Variegate porphyria79,47310710
Ehlers-Danlos Syndrome98,24910718
Langerhans cell histiocytosis38900310
MERRF syndrome5510037
Henoch-Schönlein Purpura76100618
Adult Refsum disease77300717
Kawasaki’s syndrome23310085
Reye’s syndrome30960089
Takayasu’s arteritis328700315
Whipple’s disease345200615
Bartonella50,83900716
McLeod syndrome59,30600712
Rickettsialpox83,3120077
Miller Fisher syndrome98,91900816
Polyglandular autoimmune syndrome type III227,98200813
Hughes-Stovin syndrome228,11600611
Marburg multiple sclerosis228,1570078
Arnold-Chiari malformation268,88200619
Primary antiphospholipid syndrome398,0970065
\