Table 3 Factors associated with refusal to participate in clinical trial subcategories (adjusted (aOR) odds ratios with 95% confidence intervals [95%CI] and associated significance estimates (p-values) for variables used to predict refusal)
Trial Subcategory | Willingness to participate rate | Factors associated with refusal to participate | aOR [95%CI] | p-value |
|---|---|---|---|---|
Drug Pre-marketing | 246/838 (29%) | - Gender (female) | 0.64 [0.47–0.88] | 0.006 |
- Poor knowledge about own disease | 0.58 [0.39–0.88] | 0.010 | ||
- Distrust-group membership | 0.45 [0.32–0.63] | < 0.001 | ||
Drug Post-marketing | 630/838 (75%) | - Gender (female) | 0.66 [0.50–0.88] | 0.004 |
Drug (pre or post-marketing) | 638/838 (76%) | - Gender (female) | 0.67 [0.49–0.93] | 0.017 |
Public sponsor | 723/838 (86%) | - Inactive employment status | 0.56 [0.40–0.78] | < 0.001 |
Pharmaceutical sponsor | 91/838 (11%) | - Age | 0.96 [0.95–0.98] | < 0.001 |
- Distrust-group membership | 0.25 [0.14–0.44] | < 0.001 |