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Table 2 Views of Local IRBs Regarding CIRB Review

From: How local IRBs view central IRBs in the US

Perceived Problems and Ambivalence Concerning Local IRBs
   ▪ Problems concerning local IRBs often recognized
   ▪ But general wariness of CIRBs, and support for local IRBs
Perceived Advantages of Local IRBs
   ▪ Claims that local IRBs reflect community values
   ▪ Local knowledge of subjects
◦ Of vulnerable populations
◦ Therefore, easier to judge risks and benefits
   ▪ Local knowledge of PIs
◦ "Track records"/reputations
   ▪ Protecting "our own" subjects
◦ Perceived responsibilities to protect local patients
   ▪ "Curbside consults" with PIs
◦ Formal and informal
◦ Can facilitate mutual trust
◦ More dialogue
◦ Appreciation of local institutional culture
   ▪ Desires for local autonomy, authority, and comfort
◦ Against "being told what to do"
◦ Wariness of centralized, federal bureaucracy
Perceived Problems with CIRBs
   ▪ Differences between CIRBs
◦ Depends on who are members of the committee
   ▪ For-profit CIRBs may have conflicts of interest
Advantages of CIRBs
   ▪ Rarely acknowledged
   ▪ Streamlining work
◦ Saving Time
Disadvantages of Local IRBs
   ▪ Discrepancies can arise due to:
◦ Institutional culture and history
◦ Personalities
Local Members as Biased in Their Views of CIRBs?
Other Possible Solutions
   ▪ More guidance
   ▪ More regional IRBs?