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Ethics in Biomedical Research

Section edited by Beatrice Godard and Anita Ho

This section will include manuscripts that consider ethical aspects of research in biological and medical sciences, as well as ethical implications of new technologies, -omics research, and human  enhancement. Manuscripts addressing researcher behavior are also welcome in this section.

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  1. Content type: Research Article

    Obtaining prospective written consent from women to participate in trials when they are experiencing an obstetric emergency is challenging. Alternative consent pathways, such as gaining verbal consent at enrol...

    Authors: J. Lawton, N. Hallowell, C. Snowdon, J. E. Norman, K. Carruthers and F. C. Denison

    Citation: BMC Medical Ethics 2017 18:36

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  2. Content type: Research article

    There is ambiguity with regard to what counts as an acceptable level of risk in clinical research in pregnant women and there is no input from stakeholders relative to such research risks. The aim of our paper...

    Authors: Indira S. E. van der Zande, Rieke van der Graaf, Martijn A. Oudijk and Johannes J. M. van Delden

    Citation: BMC Medical Ethics 2017 18:35

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  3. Content type: Research article

    Researchers are required to seek consent from Indigenous communities prior to conducting research but there is inadequate information about how Indigenous people understand and become fully engaged with this c...

    Authors: E.F.M. Fitzpatrick, G. Macdonald, A.L.C. Martiniuk, H. D’Antoine, J. Oscar, M. Carter, T. Lawford and E.J. Elliott

    Citation: BMC Medical Ethics 2017 18:34

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  4. Content type: Research article

    Biobanks and biospecimen collections are becoming a primary means of delivering personalized diagnostics and tailoring individualized therapeutics. This shift towards precision medicine (PM) requires interacti...

    Authors: Leena Merdad, Lama Aldakhil, Rawan Gadi, Mourad Assidi, Salina Y. Saddick, Adel Abuzenadah, Jim Vaught, Abdelbaset Buhmeida and Mohammed H. Al-Qahtani

    Citation: BMC Medical Ethics 2017 18:32

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  5. Content type: Debate

    Despite the growing recognition for the need to improve the health of prisoners in Canada and the need for health research, there has been little discussion of the ethical issues with regards to health researc...

    Authors: Diego S. Silva, Flora I. Matheson and James V. Lavery

    Citation: BMC Medical Ethics 2017 18:31

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  6. Content type: Research article

    Robust technology infrastructure is needed to enable learning health care systems to improve quality, access, and cost. Such infrastructure relies on the trust and confidence of individuals to share their heal...

    Authors: Katherine K. Kim, Pamela Sankar, Machelle D. Wilson and Sarah C. Haynes

    Citation: BMC Medical Ethics 2017 18:25

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  7. Content type: Research article

    As thousands of healthy research participants are being included in small and large imaging studies, it is essential that dilemmas raised by the detection of incidental findings are adequately handled. Current...

    Authors: Eline M. Bunnik, Lisa van Bodegom, Wim Pinxten, Inez D. de Beaufort and Meike W. Vernooij

    Citation: BMC Medical Ethics 2017 18:10

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  8. Content type: Research article

    The introduction of genomics and biobanking methodologies to the African research context has also introduced novel ways of doing science, based on values of sharing and reuse of data and samples. This shift r...

    Authors: Jantina de Vries, Syntia Nchangwi Munung, Alice Matimba, Sheryl McCurdy, Odile Ouwe Missi Oukem-Boyer, Ciara Staunton, Aminu Yakubu and Paulina Tindana

    Citation: BMC Medical Ethics 2017 18:8

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  9. Content type: Research article

    Innovations in technology have contributed to rapid changes in the way that modern biomedical research is carried out. Researchers are increasingly required to endorse adaptive and flexible approaches to accom...

    Authors: Isabelle Budin-Ljøsne, Harriet J. A. Teare, Jane Kaye, Stephan Beck, Heidi Beate Bentzen, Luciana Caenazzo, Clive Collett, Flavio D’Abramo, Heike Felzmann, Teresa Finlay, Muhammad Kassim Javaid, Erica Jones, Višnja Katić, Amy Simpson and Deborah Mascalzoni

    Citation: BMC Medical Ethics 2017 18:4

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  10. Content type: Debate

    Biobanks are considered to be key infrastructures for research development and have generated a lot of debate about their ethical, legal and social implications (ELSI). While the focus has been on human genomi...

    Authors: Kim H. Chuong, David M. Hwang, D. Elizabeth Tullis, Valerie J. Waters, Yvonne C. W. Yau, David S. Guttman and Kieran C. O’Doherty

    Citation: BMC Medical Ethics 2017 18:1

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  11. Content type: Research article

    When conducting research with Indigenous populations consent should be sought from both individual participants and the local community. We aimed to search and summarise the literature about methods for seekin...

    Authors: Emily F. M. Fitzpatrick, Alexandra L. C. Martiniuk, Heather D’Antoine, June Oscar, Maureen Carter and Elizabeth J. Elliott

    Citation: BMC Medical Ethics 2016 17:65

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  12. Content type: Research article

    Ethical and regulatory guidance on the collection and use of human biospecimens (HBS) for research forms an essential component of national health systems in Sub-Saharan Africa (SSA), where rapid advances in g...

    Authors: Francis Barchi and Madison T. Little

    Citation: BMC Medical Ethics 2016 17:64

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  13. Content type: Research article

    The focus on translational research in clinical trials has the potential to generate clinically relevant genetic data that could have importance to patients. This raises challenging questions about communicati...

    Authors: David J. Pulford, Philipp Harter, Anne Floquet, Catherine Barrett, Dong Hoon Suh, Michael Friedlander, José Angel Arranz, Kosei Hasegawa, Hiroomi Tada, Peter Vuylsteke, Mansoor R. Mirza, Nicoletta Donadello, Giovanni Scambia, Toby Johnson, Charles Cox, John K. Chan…

    Citation: BMC Medical Ethics 2016 17:63

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  14. Content type: Debate

    Pediatric biobanking is considered important for generating biomedical knowledge and improving (pediatric) health care. However, the inclusion of children’s samples in biobanks involves specific ethical issues...

    Authors: Noor A. A. Giesbertz, Karen Melham, Jane Kaye, Johannes J. M. van Delden and Annelien L. Bredenoord

    Citation: BMC Medical Ethics 2016 17:59

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  15. Content type: Research article

    Returning neuroimaging incidental findings (IF) may create a challenge to research participants’ health literacy skills as they must interpret and make appropriate healthcare decisions based on complex radiolo...

    Authors: Caitlin E. Rancher, Jody M. Shoemaker, Linda E. Petree, Mark Holdsworth, John P. Phillips and Deborah L. Helitzer

    Citation: BMC Medical Ethics 2016 17:58

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  16. Content type: Research article

    Biobanks are precariously situated at the intersection of science, genetics, genomics, society, ethics, the law and politics. This multi-disciplinarity has given rise to a new discourse in health research invo...

    Authors: Keymanthri Moodley and Shenuka Singh

    Citation: BMC Medical Ethics 2016 17:57

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  17. Content type: Research article

    As in other countries, the traditional doctor-patient relationship in the Japanese healthcare system has often been characterised as being of a paternalistic nature. However, in recent years there has been a g...

    Authors: Victoria Coathup, Harriet J. A. Teare, Jusaku Minari, Go Yoshizawa, Jane Kaye, Masanori P. Takahashi and Kazuto Kato

    Citation: BMC Medical Ethics 2016 17:51

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  18. Content type: Research article

    Maximizing comprehension is a major challenge for informed consent processes in low-literacy and resource-limited settings. Application of rapid qualitative assessments to improve the informed consent process ...

    Authors: Adamu Addissie, Serebe Abay, Yeweyenhareg Feleke, Melanie Newport, Bobbie Farsides and Gail Davey

    Citation: BMC Medical Ethics 2016 17:40

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  19. Content type: Research article

    Research ethics review is a critical aspect of the research governance framework for human subjects research. This usually requires that research protocols be submitted to a research ethics committee (REC) for...

    Authors: Odile Ouwe Missi Oukem-Boyer, Nchangwi Syntia Munung and Godfrey B. Tangwa

    Citation: BMC Medical Ethics 2016 17:27

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  20. Content type: Research article

    The ethical concerns associated with HIV prevention and treatment research have been widely explored in South Africa over the past 3 decades. However, HIV cure research is relatively new to the region and sign...

    Authors: Keymanthri Moodley, Theresa Rossouw, Ciara Staunton and Christopher J. Colvin

    Citation: BMC Medical Ethics 2016 17:26

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  21. Content type: Research article

    In research ethics, the most basic question would always be, “which is an ethical issue, which is not?” Interestingly, depending on which ethics guideline we consult, we may have various answers to this questi...

    Authors: Rosemarie D. L. C. Bernabe, Ghislaine J. M. W. van Thiel and Johannes J. M. van Delden

    Citation: BMC Medical Ethics 2016 17:23

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  22. Content type: Research article

    In specific situations it may be necessary to make an exception to the general rule of informed consent for scientific research with an intervention. Earlier reviews only described subsets of arguments for exc...

    Authors: Susanne Rebers, Neil K. Aaronson, Flora E. van Leeuwen and Marjanka K. Schmidt

    Citation: BMC Medical Ethics 2016 17:9

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  23. Content type: Debate

    Depressive disorders are a common form of psychiatric illness and cause significant disability. Regulation authorities, the medical profession and the public require high safety standards for antidepressants t...

    Authors: Melvyn W. Zhang, Keith M. Harris and Roger C. Ho

    Citation: BMC Medical Ethics 2016 17:4

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  24. Content type: Research article

    Genealogical research and ancestry testing are popular recreational activities but little is known about the impact of the use of these services on clients’ biological and social families. Ancestry databases a...

    Authors: Susan E. Wallace, Elli G. Gourna, Viktoriya Nikolova and Nuala A. Sheehan

    Citation: BMC Medical Ethics 2015 16:87

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  25. Content type: Research article

    Informed consent as stipulated in regulatory human research guidelines requires that a volunteer is well-informed about what will happen to them in a trial. However researchers are faced with a challenge of ho...

    Authors: Agnes Ssali, Fiona Poland and Janet Seeley

    Citation: BMC Medical Ethics 2015 16:86

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  26. Content type: Research article

    The increasing emphasis on research, development and innovation for health in providing solutions to the high burden of diseases in the African Region has warranted a proliferation of studies including clinica...

    Authors: Marion Motari, Martin Okechukwu Ota and Joses Muthuri Kirigia

    Citation: BMC Medical Ethics 2015 16:82

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  27. Content type: Research article

    Community consultation is increasingly recommended, and in some cases, required by ethical review boards for research that involves higher levels of ethical risk such as international research and research wit...

    Authors: Leslie Shanks, Claudio Moroni, Isabel Cristina Rivera, Debbie Price, Sifa Banzira Clementine and Giovanni Pintaldi

    Citation: BMC Medical Ethics 2015 16:38

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  28. Content type: Debate

    International partnerships in research are receiving ever greater attention, given that technology has diminished the restriction of geographical barriers with the effects of globalisation becoming more eviden...

    Authors: John D Chetwood, Nimzing G Ladep and Simon D Taylor-Robinson

    Citation: BMC Medical Ethics 2015 16:36

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  29. Content type: Research article

    As sharing and secondary research use of biospecimens increases, IRBs and researchers face the challenge of protecting and respecting donors without comprehensive regulations addressing the human subject prote...

    Authors: Aaron J Goldenberg, Karen J Maschke, Steven Joffe, Jeffrey R Botkin, Erin Rothwell, Thomas H Murray, Rebecca Anderson, Nicole Deming, Beth F Rosenthal and Suzanne M Rivera

    Citation: BMC Medical Ethics 2015 16:32

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  30. Content type: Debate

    UK-based research conducted within a healthcare setting generally requires approval from the National Research Ethics Service. Research ethics committees are required to assess a vast range of proposals, diffe...

    Authors: Fiona A Stevenson, William Gibson, Caroline Pelletier, Vasiliki Chrysikou and Sophie Park

    Citation: BMC Medical Ethics 2015 16:21

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  31. Content type: Research article

    In an adaptive clinical trial (ACT), key trial characteristics may be altered during the course of the trial according to predefined rules in response to information that accumulates within the trial itself. I...

    Authors: Laurie J Legocki, William J Meurer, Shirley Frederiksen, Roger J Lewis, Valerie L Durkalski, Donald A Berry, William G Barsan and Michael D Fetters

    Citation: BMC Medical Ethics 2015 16:27

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  32. Content type: Research article

    The provision of informed consent is a prerequisite for inclusion of a patient in a clinical research project. In some countries, the legislation on clinical research authorizes a third person to provide infor...

    Authors: Anne-Marie Mendyk, Julien Labreuche, Hilde Henon, Marie Girot, Charlotte Cordonnier, Alain Duhamel, Didier Leys and Régis Bordet

    Citation: BMC Medical Ethics 2015 16:26

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  33. Content type: Research article

    Community engagement has been recognised as an important aspect of the ethical conduct of biomedical research, especially when research is focused on ethnically or culturally distinct populations. While this i...

    Authors: Paulina Tindana, Jantina de Vries, Megan Campbell, Katherine Littler, Janet Seeley, Patricia Marshall, Jennifer Troyer, Morisola Ogundipe, Vincent Pius Alibu, Aminu Yakubu and Michael Parker

    Citation: BMC Medical Ethics 2015 16:24

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  34. Content type: Debate

    In 2008, researchers reported that Timothy Brown (the ‘Berlin Patient’), a man with HIV infection and leukemia, received a stem-cell transplant that removed HIV from his body as far as can be detected. In 2013...

    Authors: Stuart Rennie, Mark Siedner, Joseph D Tucker and Keymanthri Moodley

    Citation: BMC Medical Ethics 2015 16:18

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2018 Journal Metrics

  • Citation Impact
    2.507 - 2-year Impact Factor
    2.571 - 5-year Impact Factor
    2.77 - Source Normalized Impact per Paper (SNIP)
    1.085 - SCImago Journal Rank (SJR)

    Usage 
    573,144 downloads

    Social Media Impact
    1119 mentions

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