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Ethics in Biomedical Research

Section edited by Beatrice Godard and Anita Ho

This section will include manuscripts that consider ethical aspects of research in biological and medical sciences, as well as ethical implications of new technologies, -omics research, and human  enhancement. Manuscripts addressing researcher behavior are also welcome in this section.

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  1. Content type: Commentary

    In the past decade, there has been an increase in genomic research and biobanking activities in Africa. Research initiatives such as the Human Heredity and Health in Africa (H3Africa) Consortium are contributi...

    Authors: Paulina Tindana, Aminu Yakubu, Ciara Staunton, Alice Matimba, Katherine Littler, Ebony Madden, Nchangwi Syntia Munung and Jantina de Vries

    Citation: BMC Medical Ethics 2019 20:69

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  2. Content type: Research article

    Community advisory boards (CABs) have expanded beyond high-income countries (HICs) and play an increasing role in low- and middle-income country (LMIC) research. Much research has examined CABs in HICs, but le...

    Authors: Yang Zhao, Thomas Fitzpatrick, Bin Wan, Suzanne Day, Allison Mathews and Joseph D. Tucker

    Citation: BMC Medical Ethics 2019 20:73

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  3. Content type: Research article

    Structured training in research integrity, research ethics and responsible conduct of research is one strategy to reduce research misconduct and strengthen reliability of and trust in scientific evidence. Howe...

    Authors: Priya Satalkar and David Shaw

    Citation: BMC Medical Ethics 2019 20:72

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  4. Content type: Debate

    As biobank research has become increasingly widespread within biomedical research, study-specific consent to each study, a model derived from research involving traditional interventions on human subjects, has...

    Authors: Rasmus Bjerregaard Mikkelsen, Mickey Gjerris, Gunhild Waldemar and Peter Sandøe

    Citation: BMC Medical Ethics 2019 20:71

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  5. Content type: Debate

    Research ethics is an integral part of research, especially that involving human subjects. However, concerns have been expressed that research ethics has come to be seen as a procedural concern focused on a fe...

    Authors: Angus Dawson, Sapfo Lignou, Chesmal Siriwardhana and Dónal P. O’Mathúna

    Citation: BMC Medical Ethics 2019 20:68

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  6. Content type: Research article

    HIV molecular epidemiology is increasingly recognized as a vital source of information for understanding HIV transmission dynamics. Despite extensive use of these data-intensive techniques in both research and...

    Authors: Farirai Mutenherwa, Douglas R. Wassenaar and Tulio de Oliveira

    Citation: BMC Medical Ethics 2019 20:67

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  7. Content type: Research article

    Most studies are inclined to report positive rather than negative or inconclusive results. It is currently unknown how clinicians appraise the results of a randomized clinical trial. For example, how does the ...

    Authors: Joeri K. Tijdink, Yvo M. Smulders, Lex M. Bouter and Christiaan H. Vinkers

    Citation: BMC Medical Ethics 2019 20:64

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  8. Content type: Debate

    Novel precision oncology trial designs, such as basket and umbrella trials, are designed to test new anticancer agents in more effective and affordable ways. However, they present some ethical concerns referre...

    Authors: Karolina Strzebonska and Marcin Waligora

    Citation: BMC Medical Ethics 2019 20:58

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  9. Content type: Research article

    Biobanking is a relatively new concept in Egypt. Building a good relationship with different stakeholders is essential for the social sustainability of biobanks. To establish this relationship, it is necessary...

    Authors: Ahmed S. Abdelhafiz, Eman A. Sultan, Hany H. Ziady, Ebtesam Ahmed, Walaa A. Khairy, Douaa M. Sayed, Rana Zaki, Merhan A. Fouda and Rania M. Labib

    Citation: BMC Medical Ethics 2019 20:57

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  10. Content type: Research article

    Rare Disease research has seen tremendous advancements over the last decades, with the development of new technologies, various global collaborative efforts and improved data sharing. To maximize the impact of...

    Authors: Minh Thu Nguyen, Jack Goldblatt, Rosario Isasi, Marlene Jagut, Anneliene Hechtelt Jonker, Petra Kaufmann, Laetitia Ouillade, Fruszina Molnar-Gabor, Mahsa Shabani, Eric Sid, Anne Marie Tassé, Durhane Wong-Rieger and Bartha Maria Knoppers

    Citation: BMC Medical Ethics 2019 20:55

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  11. Content type: Research article

    Engaging communities in community-based health research is increasingly being adopted in low- and middle-income countries. The use of community advisory boards (CABs) is one method of practicing community invo...

    Authors: Charmaine Khudzie Mlambo, Eva Vernooij, Roos Geut, Eliane Vrolings, Buyisile Shongwe, Saima Jiwan, Yvette Fleming and Gavin Khumalo

    Citation: BMC Medical Ethics 2019 20:50

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  12. Content type: Research article

    This article discusses our reflections on ethical and methodological challenges when conducting separate interviews with individuals in dyads in the uMkhanyakude district, South Africa. Our work is embedded in...

    Authors: Dumile Gumede, Nothando B. Ngwenya, Stella Namukwaya, Sarah Bernays and Janet Seeley

    Citation: BMC Medical Ethics 2019 20:47

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  13. Content type: Research article

    International research guidance has shifted towards an increasingly proactive inclusion of children and adolescents in health research in recognition of the need for more evidence-based treatment. Strong calls...

    Authors: Vicki Marsh, Nancy Mwangome, Irene Jao, Katharine Wright, Sassy Molyneux and Alun Davies

    Citation: BMC Medical Ethics 2019 20:41

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  14. Content type: Research article

    Paediatric research in low-income countries is essential to tackle high childhood mortality. As with all research, consent is an essential part of ethical practice for paediatric studies. Ethics guidelines rec...

    Authors: Helen Mangochi, Kate Gooding, Aisleen Bennett, Michael Parker, Nicola Desmond and Susan Bull

    Citation: BMC Medical Ethics 2019 20:32

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  15. Content type: Research article

    During the set-up phase of an international study of genetic influences on outcomes from sepsis, we aimed to characterise potential differences in ethics approval processes and outcomes in participating Europe...

    Authors: Ascanio Tridente, Paul A. H. Holloway, Paula Hutton, Anthony C. Gordon, Gary H. Mills, Geraldine M. Clarke, Jean-Daniel Chiche, Frank Stuber, Christopher Garrard, Charles Hinds and Julian Bion

    Citation: BMC Medical Ethics 2019 20:30

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  16. Content type: Debate

    Ensuring that countries have adequate research capacities is essential for an effective and efficient response to infectious disease outbreaks. The need for ethical principles and values embodied in internatio...

    Authors: Abha Saxena, Peter Horby, John Amuasi, Nic Aagaard, Johannes Köhler, Ehsan Shamsi Gooshki, Emmanuelle Denis, Andreas A. Reis and Raffaella Ravinetto

    Citation: BMC Medical Ethics 2019 20:29

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  17. Content type: Debate

    There is unanimous agreement regarding the need to ethically conduct research for improving therapy for patients admitted to hospital with acute conditions, including in emergency obstetric care. We present a ...

    Authors: Dan K. Kaye, Gershom Chongwe and Nelson K. Sewankambo

    Citation: BMC Medical Ethics 2019 20:27

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  18. Content type: Research article

    Large-scale linkage of international clinical datasets could lead to unique insights into disease aetiology and facilitate treatment evaluation and drug development. Hereto, multi-stakeholder consortia are cur...

    Authors: Shona Kalkman, Menno Mostert, Christoph Gerlinger, Johannes J. M. van Delden and Ghislaine J. M. W. van Thiel

    Citation: BMC Medical Ethics 2019 20:21

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  19. Content type: Research article

    The rapid expansion of research on Brain-Computer Interfaces (BCIs) is not only due to the promising solutions offered for persons with physical impairments. There is also a heightened need for understanding B...

    Authors: Johannes Kögel, Jennifer R. Schmid, Ralf J. Jox and Orsolya Friedrich

    Citation: BMC Medical Ethics 2019 20:18

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  20. Content type: Debate

    Even after several decades of human drug development, there remains an absence of published, substantial, comprehensive data to validate the use of animals in preclinical drug testing, and to point to their pr...

    Authors: Jarrod Bailey and Michael Balls

    Citation: BMC Medical Ethics 2019 20:16

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  21. Content type: Research article

    The consent and community engagement process for research with Indigenous communities is rarely evaluated. Research protocols are not always collaborative, inclusive or culturally respectful. If participants d...

    Authors: Emily FM Fitzpatrick, Gaynor Macdonald, Alexandra LC Martiniuk, June Oscar, Heather D’Antoine, Maureen Carter, Tom Lawford and Elizabeth J Elliott

    Citation: BMC Medical Ethics 2019 20:12

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  22. Content type: Research article

    Consent processes for clinical trials involving HIV prevention research have generated considerable debate globally over the past three decades. HIV cure/eradication research is scientifically more complex and...

    Authors: Keymanthri Moodley, Ciara Staunton, Theresa Rossouw, Malcolm de Roubaix, Zoe Duby and Donald Skinner

    Citation: BMC Medical Ethics 2019 20:9

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  23. Content type: Correspondence

    In 2017 Ploug and Holm argued that anonymizing individuals in the Danish circumcision registry was insufficient to protect these individuals from what they regard as the potential harms of being in the registr...

    Authors: Robert S. Van Howe, Morten Frisch, Peter W. Adler and J. Steven Svoboda

    Citation: BMC Medical Ethics 2019 20:6

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    The original article was published in BMC Medical Ethics 2017 18:53

  24. Content type: Research article

    Increasing adoption of electronic health records in hospitals provides new opportunities for patient data to support public health advances. Such learning healthcare models have generated ethical debate in hig...

    Authors: Daniel Mbuthia, Sassy Molyneux, Maureen Njue, Salim Mwalukore and Vicki Marsh

    Citation: BMC Medical Ethics 2019 20:3

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  25. Content type: Research article

    The rapid increase of industry-sponsored clinical research towards developing countries has led to potentially complex ethical issues to assess. There is scarce evidence about the perception of these participa...

    Authors: Gerardo González-Saldivar, René Rodríguez-Gutiérrez, Jose Luis Viramontes-Madrid, Alejandro Salcido-Montenegro, Neri Alejandro Álvarez-Villalobos, Victoria González-Nava and José Gerardo González-González

    Citation: BMC Medical Ethics 2019 20:2

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  26. Content type: Debate

    Thus far, little work in bioethics has specifically focused on global health research priority-setting. Yet features of global health research priority-setting raise ethical considerations and concerns related...

    Authors: Bridget Pratt, Mark Sheehan, Nicola Barsdorf and Adnan A. Hyder

    Citation: BMC Medical Ethics 2018 19:94

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  27. Content type: Research article

    In Switzerland, research with identifiable human tissue samples, and/or its accompanying data, must be approved by a research ethics committee (REC) before it can be allowed to take place. However, as the dema...

    Authors: Flora Colledge, Sophie De Massougnes and Bernice Elger

    Citation: BMC Medical Ethics 2018 19:93

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    The Correction to this article has been published in BMC Medical Ethics 2019 20:24

  28. Content type: Study protocol

    Randomized controlled trial (RCT) trial designs exist on an explanatory-pragmatic spectrum, depending on the degree to which a study aims to address a question of efficacy or effectiveness. As conceptualized b...

    Authors: Stuart G. Nicholls, Kelly Carroll, Jamie Brehaut, Charles Weijer, Spencer Phillips Hey, Cory E. Goldstein, Merrick Zwarenstein, Ian D. Graham, Joanne E. McKenzie, Lauralyn McIntyre, Vipul Jairath, Marion K. Campbell, Jeremy M. Grimshaw, Dean A. Fergusson and Monica Taljaard

    Citation: BMC Medical Ethics 2018 19:90

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  29. Content type: Research article

    A challenge of performing research in the paediatric emergency and acute care setting is obtaining valid prospective informed consent from parents. The ethical issues are complex, and it is important to consid...

    Authors: Jeremy Furyk, Kris McBain-Rigg, Bronia Renison, Kerrianne Watt, Richard Franklin, Theophilus I. Emeto, Robin A. Ray, Franz E. Babl and Stuart Dalziel

    Citation: BMC Medical Ethics 2018 19:89

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  30. Content type: Research article

    Rapid Ethical Assessment (REA) is an approach used to design context tailored consent process for voluntary participation of participants in research including human subjects. There is, however, limited eviden...

    Authors: Alem Gebremariam, Alemayehu Worku Yalew, Selamawit Hirpa, Abigiya Wondimagegnehu, Mirgissa Kaba, Mathewos Assefa, Israel Mitiku, Eva Johanna Kantelhardt, Ahmedin Jemal and Adamu Addissie

    Citation: BMC Medical Ethics 2018 19:87

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  31. Content type: Research article

    Research funders, regulatory agencies, and journals are increasingly expecting that individual-level data from health research will be shared. Broad consent to such sharing is considered appropriate, feasible ...

    Authors: Phaik Yeong Cheah, Nattapat Jatupornpimol, Borimas Hanboonkunupakarn, Napat Khirikoekkong, Podjanee Jittamala, Sasithon Pukrittayakamee, Nicholas P. J. Day, Michael Parker and Susan Bull

    Citation: BMC Medical Ethics 2018 19:86

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  32. Content type: Debate

    The U.S. National Institute of Allergies and Infectious Diseases (NIAID) and the National Institute of Mental Health (NIMH) have a new research priority: inclusion of terminally ill persons living with HIV (PL...

    Authors: Karine Dubé, Sara Gianella, Susan Concha-Garcia, Susan J Little, Andy Kaytes, Jeff Taylor, Kushagra Mathur, Sogol Javadi, Anshula Nathan, Hursch Patel, Stuart Luter, Sean Philpott-Jones, Brandon Brown and Davey Smith

    Citation: BMC Medical Ethics 2018 19:83

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  33. Content type: Research article

    The use of lengthy, detailed, and complex informed consent forms (ICFs) is of paramount concern in biomedical research as it may not truly promote the rights and interests of research participants. The extent ...

    Authors: Juntra Karbwang, Nut Koonrungsesomboon, Cristina E. Torres, Edlyn B. Jimenez, Gurpreet Kaur, Roli Mathur, Eti N. Sholikhah, Chandanie Wanigatunge, Chih-Shung Wong, Kwanchanok Yimtae, Murnilina Abdul Malek, Liyana Ahamad Fouzi, Aisyah Ali, Beng Z. Chan, Madawa Chandratilake, Shoen C. Chiew…

    Citation: BMC Medical Ethics 2018 19:79

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  34. Content type: Research article

    Cell line immortalisation is a growing component of African genomics research and biobanking. However, little is known about the factors influencing consent to cell line creation and immortalisation in African...

    Authors: Megan M. Campbell, Jantina de Vries, Sibonile G. Mqulwana, Michael M. Mndini, Odwa A. Ntola, Deborah Jonker, Megan Malan, Adele Pretorius, Zukiswa Zingela, Stephanus Van Wyk, Dan J. Stein and Ezra Susser

    Citation: BMC Medical Ethics 2018 19:72

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  35. Content type: Research article

    Deep brain stimulation (DBS) as investigational intervention for symptomatic relief from Alzheimer disease (AD) has generated big expectations. Our aim is to discuss the ethical justification of this research ...

    Authors: Merlin Bittlinger and Sabine Müller

    Citation: BMC Medical Ethics 2018 19:41

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  36. Content type: Research article

    Since 2010, the European Journal of Anaesthesiology has required the reporting of five items concerning ethical approval in articles describing human research: ethics committee’s name and address, chairperson’...

    Authors: Davide Zoccatelli, Martin R. Tramèr and Nadia Elia

    Citation: BMC Medical Ethics 2018 19:57

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  37. Content type: Research article

    Mozambique has seen remarkable growth in biomedical research over the last decade. To meet a growing need, the National Committee for Bioethics in Health of Mozambique (CNBS) encouraged the development of ethi...

    Authors: Jahit Sacarlal, Vasco Muchanga, Carlos Mabutana, Matilde Mabui, Arlete Mariamo, Assa Júlio Cuamba, Leida Artur Fumo, Jacinta Silveira, Elizabeth Heitman and Troy D. Moon

    Citation: BMC Medical Ethics 2018 19:37

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  38. Content type: Research article

    With the growing amount of clinical research, regulations and research ethics are becoming more stringent. This trend introduces a need for quality assurance measures for ensuring adherence to research ethics ...

    Authors: Sinyoung Park, Chung Mo Nam, Sejung Park, Yang Hee Noh, Cho Rong Ahn, Wan Sun Yu, Bo Kyung Kim, Seung Min Kim, Jin Seok Kim and Sun Young Rha

    Citation: BMC Medical Ethics 2018 19:30

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  39. Content type: Research article

    Compensation for research related injuries is a subject that is increasingly gaining traction in developing countries which are burgeoning destinations of multi center research. However, the existence of dispa...

    Authors: George Rugare Chingarande and Keymanthri Moodley

    Citation: BMC Medical Ethics 2018 19:8

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  40. Content type: Debate

    The participation of vulnerable patients in clinical research poses apparent ethical dilemmas. Depending on the nature of the vulnerability, their participation may challenge the ethical principles of autonomy...

    Authors: Gert J. van der Wilt, Janneke P. C. Grutters, Angela H. E. M. Maas and Herbert J. A. Rolden

    Citation: BMC Medical Ethics 2018 19:5

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  41. Content type: Debate

    Fake news and alternative facts have become commonplace in these so-called “post-factual times.” What about medical research - are scientific facts fake as well? Many recent disclosures have fueled the claim t...

    Authors: Bjørn Hofmann

    Citation: BMC Medical Ethics 2018 19:4

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  42. Content type: Research article

    For valid informed consent, it is crucial that patients or research participants fully understand all that their consent entails. Testing and revising informed consent documents with the assistance of their ad...

    Authors: Sabine Bossert, Hannes Kahrass, Ulrike Heinemeyer, Jana Prokein and Daniel Strech

    Citation: BMC Medical Ethics 2017 18:78

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  43. Content type: Research article

    Community engagement (CE) models have provided much needed guidance for researchers to conceptualise and design engagement strategies for research projects. Most of the published strategies, however, still sho...

    Authors: Rosemary Musesengwa and Moses J. Chimbari

    Citation: BMC Medical Ethics 2017 18:76

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  44. Content type: Debate

    The use of tissue collected at a forensic post-mortem for forensic genetics research purposes remains of ethical concern as the process involves obtaining informed consent from grieving family members. Two for...

    Authors: Laura J. Heathfield, Sairita Maistry, Lorna J. Martin, Raj Ramesar and Jantina de Vries

    Citation: BMC Medical Ethics 2017 18:66

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2018 Journal Metrics

  • Citation Impact
    2.507 - 2-year Impact Factor
    2.571 - 5-year Impact Factor
    2.77 - Source Normalized Impact per Paper (SNIP)
    1.085 - SCImago Journal Rank (SJR)


    Social Media Impact
    1119 mentions