From: Unapproved clinical trials in Russia: exception or norm?
No | Journal article | Approved indications | Approved conditions of use | Clinical trial approved by the MoH | Randomisation | Advertising | Duplication |
---|---|---|---|---|---|---|---|
1 | Comparison of clinical efficacy and safety of the two drugs in the therapy of symptoms of eruption of infant teeth (“Dantinorm Baby®” vs “Calgel®””) [10] | + | + | − | + | + | − |
2 | Nonsteroid anti-inflammatory drugs for the treatement of osteoarthrosis: comparative efficacy and tolerability of nimesulide [11] | + | + | − | + | + | − |
3 | Efficiency of butyric acid and inulin in patients with irritable bowels syndrome: results of multicenter study [12] | − | − | − | + | + | − |
4 | Efficiency of different schemes of antihelicbacter therapy in patients with chronic gastroduodenal diseases and type 2 diabetes mellitus [13] | − | − | − | − | − | No. 12 |
5 | Enterosorption in the treatment of duodenal ulcer in children in the settings of Helicobacter pylori infection and Candida colonization [14] | − | − | − | + | − | No. 24 |
6 | Antihypertensive efficacy of chronopharmacotherapeutical approach to arterial hypertension in post transient ischemic attack patients [15] | + | + | − | + | + | − |
7 | Evaluation of the Reactogenicity, Safety and Immunogenicity of the Domestic Influenza Inactivated Split FLU-M Vaccine in Immunization Adults aged 18-60 Years [16] | + | + | + | + | − | − |
8 | Vitabact in the treatment of inflammatory diseases of eyes in the conditions of neuro reanimation [17] | + | − | − | − | − | − |
9 | Open prospective randomized study of the results of using Venarus in postthrombotic disease [18] | + | + | − | + | + | − |
10 | Clinical evaluation of the efficacy of azoxime boviolaluronidase in the prevention of excessive scarring after surgical treatment of glaucoma [19] | + | − | − | + | − | − |
11 | Study of clinical efficacy of original and generic drugs of ivabradine in patients with stable angina (comparative study)[20] | + | + | ? | + | + | − |
12 | New aspects of eradicative anti-helicobacter pylori in type 2 diabetic patients with chronic gastroduodenal disorders [21] | − | − | − | − | − | No. 4 |
13 | Estimation of hypolipidemic psillium effect in gastroenterologic patients with lipid metabolism disorders [22] | − | − | − | − | − | − |
14 | The inhalation therapy of moderate forms of acute bacterial rhinosinusitis [23] | − | − | − | + | + | − |
15 | Experience of the usage of Tonsilgon® N in the complex treatment of chronic tonsillitis with irrigations of palatine tonsils in adults [24] | + | + | − | + | + | − |
16 | Efficiency and safety of chemotherapy regimen with SQ109 in those suffering [25] | − | − | + | + | + | − |
17 | Anhedonia, depression, anxiety, and craving in opioid dependent patients stabilized on oral naltrexone or naltrexone implant [26] | + | + | − | + | − | − |
18 | Alcohol withdrawal syndrome dynamics during treatment with Nooclerin (deanoli aceglumas) [27] | + | + | − | + | + | − |
19 | Indicators’ dynamics of electrophysiological non-homogeneity of myocardium on the patients’ intensive statinology in postinfarctic period [28] | + | − | − | −/+ | − | − |
20 | Results of the intermittent regimen of initial pain therapy with chondroitin sulfate and glucosamine sulfate for patients with osteoarthritis, back pain and comorbidity [29] | + | + | − | + | + | − |
21 | Observational study of the efficiency and safety of the use of tenoxicam in dorsalgy in comparison with meloxicam and [30] | + | + | − | + | + | − |
22 | Evaluation of efficacy and safety of rebamipide use in the triple therapy for Helicobacter pylori eradication: a pilot study [31] | + | + | − | + | + | − |
23 | Immunogenicity of the third generation hepatitis b vaccine (pre-S1/pre-S2/S) [32] | − | − | + | + | − | − |
24 | Enterosorption in the treatment of duodenal ulcer in children in the settings of helicobacter pylori infection and candida colonization [33] | − | − | − | + | + | No. 5 |
25 | Effectiveness of the tenoxicam in patients with ankylosing spondylitis [34] | + | + | − | + | − | − |
26 | Efficiency of combined antihypertensive therapy in patients with arterial hypertension and obesity depending on the polymorphism of CYP2C9 gene [35] | + | + | − | −/+ | − | − |