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Table 2 Summary results of five initial Lung-MAP sub-studies [17]

From: Umbrella and basket trials in oncology: ethical challenges

Sub-study ClinicalTrials.gov identifier Final accrual Response rate to investigational therapy N (%) Comment
S1400A (non-match) NCT02766335 Total: 116 11 (16) Administratively closed to enable activation of a new non-match study
Chemotherapy: 38
MEDI4736: 78
S1400B NCT02785913 Total: 39 1 (4) Failed to meet its primary endpoint,closed at interim futility analysis
Chemotherapy: 8
GDC-0032: 31
S1400C NCT02785939 Total: 54 2 (6) Failed to meet its primary endpoint,closed at interim futility analysis
Chemotherapy: 17
Palbociclib: 37
S1400D NCT02965378 Total: 45 2 (7) Failed to meet its primary endpoint, closed at interim futility analysis
Chemotherapy: 10
AZD4547: 35
S1400E NCT02926638 Total: 9 N/A Closed early due to discontinuation of development of rilotumumab
Erlotinib: 5
Erlotinib + Rilotumumab: 4