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Fig. 2 | BMC Medical Ethics

Fig. 2

From: Umbrella and basket trials in oncology: ethical challenges

Fig. 2

The schema of NCI-MATCH study design. The biopsy material derived from registered patients is characterized for specific pre-defined mutations via genetic sequencing. If an actionable mutation is detected, patients are assigned to 1 of 30 treatment sub-protocols. Those experiencing disease progression or serious adverse events undergo review of their previous biopsy results or undergo another biopsy to search for alternative treatment [10]

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