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Table 3 Two profiles of respondents

From: Exploring neurologists’ perspectives on the return of next generation sequencing results to their patients: a needed step in the development of guidelines

Profiling respondents… a
Profile A (n = 120; 58.5%) Profile B (n = 65; 31.8%)
- Would offer WGS to all their patients or do so in limited circumstances - Would not offer WGS to their patients, or did not know about the uses of WGS
- Treating mainly children - Treating mainly adults
Returning WGS results to patients by Profile
 - An unexpected result should always be about a disease for which effective preventive interventions or treatment are available
No difference between profiles
 - An unexpected result should always indicate a high probability to develop a specific disease (as opposed to a result indicating a low probability to develop a disease
Profile A tended to agree (p < .001)
 - An unexpected result should always be about a disease whose onset may be expected in a near future
Profile A tended to agree (p < .001)
 - Parents or other proxies should remain free to choose not to know about unexpected finding in the patient’s W GS, including findings about preventable or treatable disease
Profile B tended to agree (p < .001)
 - Conveying genetic results with uncertain clinical significance if requested by parents or proxies
Profile A respondents were more inclined (p < .001)
 - Analysis of genomics data should be limited to the genes likely to be relevant to the patient’s specific medical condition, so as to limit unexpected findings
Profile A tended to agree (p < .001)
Recontacting patients by Profile
 - Neurologists have the responsibility to recontact and inform their patients of clinically significant, newly discovered mutations that were linked to their neurological condition
Profile A tended to agree (p < .001)
 - Neurologists have the responsibility to recontact and inform their patients of clinically significant, newly discovered and for IFs
Profile A tended to agree (p < .05)
 - The responsibility to return results should be for as long as neurologists are treating the patient
Profile A tended to agree (p < .05)
  1. aBased on χ2 and factor analyses. A one-way ANOVA was conducted to compare the two profiles. We considered a P-value of 0.05 or less as statistically significant [23]