Table 6 Answers to question 7. “What are “compelling and scientifically sound methodological reasons” as outlined in paragraph 32 of the Declaration of Helsinki for your institution which would justify the use of placebo?”
Compelling and scientifically sound methodological reasons | Country |
|---|---|
Questionable effectiveness of standard treatment | Armenia, Canada, Cuba, Israel, Namibia |
Assay sensitivity/ when placebo is the most rigorous test of efficacy | Germany, Ghana, USA, The EU |
No current proven intervention exists | Namibia, Uganda, Zimbabwe |
High placebo response rate | Canada, Chile, Cuba |
None if effective treatment exists | Japan, United Arab Emirates, Zimbabwe |
Standard treatment is too toxic | Ghana, Tanzania |
Available treatment is too expensive | Botswana, Uganda |
Non-responders | Israel, Tanzania |
Add on | Ghana, Saudi Arabia |
Size of placebo groups may be smaller than in active control studies | Saudi Arabia |