Table 1 Options for communication of PGx data to trial participants

Option 1: Not to proactively communicate either the individual or aggregate research results to patients; the results will be published in scientific journals.

Option 2: Communicate a summary of the aggregate research results to patients, and provide them with the option to receive or not receive their individual (research-quality) BRCA result

Option 3: Communicate a summary of the aggregate research results and encourage patients who have not had a diagnostic-quality BRCA test to seek pre-test counselling and a diagnostic BRCA test.