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Informed consent instead of assent is appropriate in children from the age of twelve: Policy implications of new findings on children’s competence to consent to clinical research

  • Irma M. Hein1Email author,
  • Martine C. De Vries2,
  • Pieter W. Troost1,
  • Gerben Meynen3, 4,
  • Johannes B. Van Goudoever5, 6 and
  • Ramón J. L. Lindauer1
BMC Medical Ethics201516:76

Received: 29 June 2015

Accepted: 19 October 2015

Published: 9 November 2015

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Open Peer Review reports

Pre-publication versions of this article are available by contacting

Original Submission
29 Jun 2015 Submitted Original manuscript
13 Jul 2015 Reviewed Reviewer Report - Emma Cave
16 Aug 2015 Reviewed Reviewer Report - Katherine Wade
1 Sep 2015 Author responded Author comments - Irma Hein
Resubmission - Version 2
1 Sep 2015 Submitted Manuscript version 2
19 Oct 2015 Editorially accepted
9 Nov 2015 Article published 10.1186/s12910-015-0067-z

How does Open Peer Review work?

Open peer review is a system where authors know who the reviewers are, and the reviewers know who the authors are. If the manuscript is accepted, the named reviewer reports are published alongside the article. Pre-publication versions of the article are available by contacting

You can find further information about the peer review system here.

Authors’ Affiliations

Department of Child and Adolescent Psychiatry, Academic Medical Center, Amsterdam, Netherlands
Department of Medical Ethics and Health Law, Leiden University Medical Center, Leiden, Netherlands
Faculty of Philosophy, VU University Amsterdam, Amsterdam, Netherlands
Tilburg Law School, Tilburg University, Tilburg, Netherlands
Academic Medical Center, Emma’s Children Hospital, Amsterdam, Netherlands
Department of Pediatrics, VU University Medical Center, Amsterdam, Netherlands