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Table 1 CYP enzymes in humans, rat, mouse, dog and monkey

From: The Nuremberg Code subverts human health and safety by requiring animal modeling

CYP 450 enzyme

Family

Subfamily

Gene

 

Human

Monkey

Dog

Rat

Mouse

1

A

1, 2

1, 2

1, 2

1, 2

1, 2

2

A

6, 7, 13

23, 24

13, 25

1, 2, 3

4, 5, 12, 22

2

B

6

17

11

1-3, 8, 12, 15, 21

9, 10, 13, 19, 23

2

C

8, 9, 18, 19

20, 74, 75, 76

21, 41

6, 7, 11–13, 22–24, 46

29, 37–40, 44, 50

2

D

6

1, 7, 42

15

1-5, 18

9-13, 22, 26, 34, 40

2

E

1

1

1

1

1

3

A

4, 5, 7, 43

6, 8, 64, 66

12, 26

1, 2, 9, 18, 23, 62

11, 13, 16, 25, 41, 44, 57, 59

  1. Cytochrome P450 (CYP) is a superfamily of enzymes and are the major drug-metabolizing enzymes.
  2. CYP enzymes are categorized as CYP letter_number_letter. The first number is the gene family, the letter is the subfamily, and the final number is the individual gene. Some subfamilies have enzymes from several different genes. (Adopted and based on data from[58–60]).
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BMC Medical Ethics

ISSN: 1472-6939

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