Table 1 Case study details

Perfusion study (PS)

2 years

July 2008

2-6 months

400 children

· A RCT, severely ill, admitted with shock. Venous blood draws: admission, 8 hrs, 24 hrs& 48 hrs

Hospital

· Follow up (f/up) day 28/60 after discharge

TB study

2 years

Sep 2009

6 months

1500 children

· Severely ill, inpatient children with suspected TB. All children managed using WHO standards.

Hospital

· Venous blood samples taken; 1 or 2 f/ups decided upon by clinician

Respiratory infections I (RSV I)

4 months

Jan 2009

Approx 20-30mins

400 children

· Study to evaluate nasopharyngeal sampling tool

Community Health Centre

· Nasal samples collected using swabs/nasal wash

Malaria Vaccine (MV)

3 years

Jan 2009

3 years

1000 children

· A large Multicenter Vaccine trial. Trial vaccines injected 3 different times; 5 venous blood draws.

Community

· F/ups at homes every 6 days after injections; monthly follow up between injections

Immunology (Immuno)

5 years

2006

5 years

5000 children

· Cohort study of natural malaria immunity in children, recruited at birth

Community

· 1 annual blood draw but a 5 ml sample at any fever event

Weekly f/up visits at homes by FWs.

Respiratory Infections II (RSV II)

4 months

Oct 2009

4 months

50 household members

· A study to identify pattern of infection

Community

· Children who were born in previous epidemic and have elder sibling

· Nasal swabbing twice a week at participants’ homes; saliva samples once a week

HIV study (HIV)

10 years

2006

>2 years

30

· Men who have sex with men (MSM), enrolled in a longitudinal observational HIV study.

Community

· F/ups: weekly-month 1, Bi-weekly-month 2, then monthly for minimum 2 years

· 50 ml blood drawn per f/up

Verbal autopsy (VA)

>2 years

July 2008

30-45 mins

1000 p.a.

· Relatives of deceased persons interviewed (30-45mins)

Community

·Interviews done at participants’ homes