Table 1 Test characteristics of personal genome testing and their implications for the discourse on ELSI
Test characteristic | Implications | ELSI |
|---|---|---|
From targeted to non-targeted testing | Quantity and complexity of information | The information problem - Informed consent - Information provision (pre-test and post-test) - Informational updates - Incidental findings |
Analytical validity | High analytical validity | Regulatory issues |
Clinical validity | Generally poor clinical validity (validity varies per disease tested for) | - Psychological risks, health risks and societal risks - Regulatory issues |
Clinical utility | Generally poor clinical utility (utility varies per disease tested for) | - Personal perspectives on utility - Changing interpretations (fluidity of information) |